Tetanus antitoxin instructions
　　Warning: Those with positive allergic test should be used with caution, see desensitization injection for details

　　【Drug Name】Generic Name: Tetanus Antitoxin
　　English name: Tetanus Antitoxin
　　Hanyu Pinyin: Poshangfeng Kangdusu
　　Ingredients and properties】The main component of this product: horse tetanus immunoglobulin after digestion by gastric enzymes.
　　This product is a liquid antitoxin globulin preparation made from plasma obtained from tetanus toxoid-immunized horses, purified by gastric enzyme digestion.
　　Excipients: sodium chloride, m-cresol.
　　Finished product dosage form: injection.
　　Appearance: This product is a colorless or light yellow clear liquid, containing a small amount of preservative, and a small amount of precipitate that can be shaken off can be precipitated after a long time.
　　[Vaccination target]: Open trauma (especially deep wounds and serious pollution) with risk of tetanus infection.
　　【Role and application】This product contains specific antibodies and has the effect of neutralizing tetanus toxin, and can be used for the prevention of Clostridium tetani infection.
　　Specification】0.75ml,1500IU/pc.
　　Immunization procedure and dose
　　Inoculation site: subcutaneous or intramuscular.
　　Inoculation route: subcutaneous injection should be at the upper arm deltoid muscle attachment. Intramuscular injection should be given in the middle of the deltoid muscle of the upper arm or the upper part of the external gluteus maximus muscle.
　　Dose: 1 subcutaneous or intramuscular injection of 1500~3000 IU, the same dosage for children and adults; the dosage can be increased by 1~2 times for serious injuries. After 5~6 days, if the risk of tetanus infection is not eliminated, the injection should be repeated.
　　Adverse reactions】1. Anaphylaxis: It can occur suddenly during or within minutes to tens of minutes after injection. Patients suddenly show depression or irritability, pale or flushed face, chest tightness or shortness of breath, cold sweat, nausea or abdominal pain, fine and rapid pulse, decreased blood pressure, and in severe cases, delirium and deficiency, and can die quickly if not rescued in time. The mild cases can be relieved by injection of epinephrine; the severe cases need to be infused with oxygen, use of antihypertensive drugs to maintain blood pressure, and use of anti-allergic drugs and adrenocorticotropic hormones for resuscitation.
　　Serum sickness: The main symptoms are urticaria, fever, enlarged lymph nodes, local swelling, occasional proteinuria, vomiting, arthralgia, erythema, itching and edema at the injection site. The onset of the disease is usually 7~14 days after injection, which is called delayed type. There are also cases where the disease develops 2~4 days after injection, which is called accelerated type. The serum disease should be treated symptomatically, calcium or antihistamine drugs can be used, generally a few days to ten days to heal.
　　[Contraindications] Use with caution if the allergy test is a positive reaction, see desensitization injection method for details.
　　Precautions】｜
　　1. This product is a liquid product. The product should not be used if it is cloudy, has precipitates that cannot be shaken or foreign matter, or if the ampoule is cracked or the label is unclear or expired. The ampoule should be used up at once after opening.
　　2. Detailed records should be kept for each injection, including name, gender, age, address, number of injections, reaction after the last injection, results of the allergy test and reaction after the injection, name and batch number of the antitoxin used, etc.
　　3. Injection equipment and injection sites should be strictly disinfected. Syringes should be used exclusively, and if not, they should be thoroughly washed and sterilized after use, preferably by dry baking or autoclaving, while syringes should be separated when injecting toxoid.
　　4. Special attention should be paid to the prevention of allergic reactions when using antitoxins. Allergy testing and detailed inquiry of previous allergy history must be done before injection. Anyone who has a history of bronchial asthma, cushings fever, eczema or angioneurotic edema, or who is allergic to a substance, or who has been injected with equine serum preparations in the past, must be especially careful about the occurrence of allergic reactions.

　　(1) Allergy test: dilute the antitoxin 10 times with sodium chloride injection (0.1 ml of antitoxin plus 0.9 ml of sodium chloride injection), inject 0.05 ml intradermally on the forefoot side and observe for 30 minutes. If there is no obvious reaction at the injection site, it is considered negative, and the antitoxin can be injected directly under close observation. If the injection site shows enlarged mounds, redness, swelling and infiltration, especially if it resembles pseudopod or has an itchy feeling, it is a positive reaction and must be injected by desensitization method. If the local reaction to the injection is particularly severe or accompanied by systemic symptoms, such as urticaria, nasopharyngeal itching, sneezing, etc., it is a strong positive reaction and the use of antitoxin should be avoided. If it is necessary to use it, desensitization injection should be used, and be prepared for resuscitation in case of anaphylaxis. People with no history of allergy or those with negative allergic reactions are not free from the possibility of anaphylaxis. In order to be cautious, a small amount can be injected subcutaneously first for testing, and then the full amount can be injected subcutaneously or intramuscularly after 30 minutes of observation and no abnormal reaction.
　　(2) Desensitization injection method: In general, the antitoxin can be diluted 10 times with sodium chloride injection and injected subcutaneously in small amounts several times and observed for 30 minutes after each injection. If there is no cyanosis, shortness of breath or significant shortness of breath and accelerated pulse, the second injection of 0.4 ml can be given, and if there is still no response, the third injection of 0.8 ml can be given. If there is a history of allergy or a strong positive allergy test, the amount of the first injection and subsequent increments should be reduced appropriately and divided into multiple injections to avoid severe reactions.
　　5. After outpatient injection of antitoxin, patients should be observed for 30 minutes before leaving.
　　Storage]: Store in a dry place at 2~8℃ away from light. Transportation: 2~8℃, dry and protected from light.
　　Package】Ampoule, 10pcs/box.
　　Expiration date】36 months
　　Standard】Chinese Pharmacopoeia, 2015 Edition, Part III
　　Approval number】S10970021
　　【Manufacturing enterprise
　　Company Name: Jiangxi Institute of Biological Products Co.
　　Production Address: Jinggangshan Economic and Technological Development Zone, Ji'an City, Jiangxi Province
　　Postal Code: 343100

　　Phone number：0796-8403918
　　Fax Number：0796-8403906
　　Website：http://www.jxswzp.cn/